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Старый 11.09.2014, 06:29   #11
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OZ
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"At a conference breakout, several leading geneticists fielded questions about genetic diseases and DNA testing. One question reflected common confusion among breeders about the DNA test now available for a mutation associated with Degenerative Myelopathy (DM): What does the test mean and how should breeders use it?
DM generally develops in older dogs and has been reported in a number of breeds (including Poodles, although uncommon). Since other problems may clinically resemble DM, the disease can only be diagnosed after death by microscopic examination of the spinal cord. For more info on DM, see www.offa.org/dnatesting/dm.html.
Researchers at the University of Missouri and the Broad Institute found that dogs with DM always have two copies of a certain gene mutation, and a DNA test for the mutation is available through OFA. However, panel geneticists stressed that having two copies of the mutated gene does NOT mean a dog is “affected” and will develop DM; it means a dog is “at risk” for the disease if the disorder is found in that breed. Evidence is mounting that other factors must be present for a dog to develop DM, such as other genes, epigenetics and environmental influences. But these factors are yet unknown. The mutated gene associated with DM has been around for a long time. So far, it has been found in more than 100 breeds, with a very high incidence in some, including breeds with no reported cases of DM. More than 90 percent of Wire Fox Terriers, for example, have two copies of the mutated gene associated with DM, but DM has never been reported in Wire Fox Terriers. Panel members recommended using the DNA test if DM has been diagnosed in a dog’s close relatives, which suggests that other genetic factors are more common in that line of dogs.”
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