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[wild rose country]

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ETEC is largely a pathogen of developing countries, and it is well known that these countries typically have a low rate of colon cancer. Pitari et al.56 have reported that STa suppresses colon cancer cell proliferation through a guanylyl cyclase C-mediated signalling cascade. So the high prevalence of ETEC in developing countries might have a protective effect against this important disease, and indicates that infectious diseases might exist in a complex evolutionary balance with their human populations.